Best Answer Explained in Below-:

Rule: ‘in spite of’, ‘despite’ and ‘although’ are all used to show contrast and are used for the same meaning. The only difference is the way they are used; the structure in which they are used. Rule: ‘in spite of’ and ‘despite’ are placed in front of a noun or pronoun: Example 1. We had a great time in spite of the rain. 2. We had a great time despite the rain. 3. Despite studying very hard, he still didn’t pass the exam. ‘studying’ is the noun form of the verb ‘study’ rule: ‘although’ is used in front of a subject and a verb: Example: We had a great time although it rained. Although he studied very hard, he still didn’t pass the exam. Rule: If ‘in spite of’ and ‘despite’ are used in front of the phrase ‘the fact that’ then they can be used with a subject and a verb: Example: 1. In spite of the fact that he studied very hard, he still didn’t pass the exam. 2. Despite the fact that it rained we still had a great time.